Chronicles of EK

April 11, 2012
We are always told, as a lab, what an amazing speaker Eric is. While we will try and get you one of his talks in AV format, here are a few pictures of Eric explaining mTOR in neurodevelopment at the Tokyo Metropolitan Institute of Medical Sciences in March 2013:       Eric is curr...

Reversal of Impaired Hippocampal Long-Term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors

May 31, 2012
Hanoch Kaphzan, Pepe Hernandez, Joo In Jung, Kiriana K. Cowansage, Katrin Deinhardt, Moses V. Chao, Ted Abel, Eric Klann ...

Fragile X syndrome therapeutics S(C)TEP through the developmental window

May 31, 2012
Aditi Bhattacharya and Eric Klann ...

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

June 12, 2012
Mimi A Trinh, Hanoch Kaphzan, Ronald C. Wek, Philippe Peirre, Douglas R. Cavener and Eric Klann ...

The molecular basis of cognitive deficits in pervasive developmental disorders.

October 2, 2012
Aditi Bhattacharya and Eric Klann Persons with pervasive developmental disorders (PDD) exhibit a range of cognitive deficits that hamper their quality of life, including difficulties involving communication, sociability, and perspective-taking. In recent years, a va...

Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer’s Disease Model Mice.

October 5, 2012
Tao Ma, Xueliang Du, Joseph E. Pick, Guangzhi Sui, Micheal Brownlee, and Eric Klann   ...

Multiple Components of eIF4F are Required for Protein Synthesis-dependent Hippocampal Long-term Potentiation.

October 22, 2012
Charles. A. Hoeffer, Emanuela Santini, Tao Ma, Elizabeth C. Arnold, Ashley M. Whelan, Helen Wong, Philip Pierre, Jerry Pelletier, and Eric Klann ...

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

October 22, 2012
Aditi Bhattacharya, Hanoch Kaphzan, Amanda C. Alvarez-Dieppa, Jacyln P. Murphy, Philippe Pierre, and Eric Klann ...

Neuronal Expression of the Ubiquitin E3 ligase APC/C-Cdh1 During Development is Required for Long-term Potentiation, Behavioral Flexibility, and Extinction

December 18, 2012
Joseph E. Pick, Li Wang, Joshua E. Mayfield, and Eric Klann ...

The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice

December 18, 2012
Joseph E. Pick,  Marco Malumbres, and Eric Klann