The translation of translational control by FMRP: therapeutic targets for FXS

April 18, 2013
Jennifer C. Darnell, and Eric Klann http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.3379.html De novo protein synthesis is necessary for long-lasting modifications in synaptic strength and dendritic spine dynamics that underlie cognition. Fragile X syndrome (FXS), characterized by intellectual disability...
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Exaggerated translation causes synaptic and behavioural aberrations associated with autism

December 26, 2012
Emanuela Santini, Thu N. Huynh, Andrew F. Macaskill, Adam G. Carter, Philippe Pierre, Davide Ruggero, Hanoch Kaphzan, and Eric Klann http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11782.html ...
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The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice

December 18, 2012
Joseph E. Pick,  Marco Malumbres, and Eric Klann http://learnmem.cshlp.org/content/20/1/11.full...
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Neuronal Expression of the Ubiquitin E3 ligase APC/C-Cdh1 During Development is Required for Long-term Potentiation, Behavioral Flexibility, and Extinction

December 18, 2012
Joseph E. Pick, Li Wang, Joshua E. Mayfield, and Eric Klann http://www.sciencedirect.com/science/article/pii/S1074742712001773 ...
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Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

October 22, 2012
Aditi Bhattacharya, Hanoch Kaphzan, Amanda C. Alvarez-Dieppa, Jacyln P. Murphy, Philippe Pierre, and Eric Klann http://www.cell.com/neuron/abstract/S0896-6273(12)00673-3?switch=standard ...
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Multiple Components of eIF4F are Required for Protein Synthesis-dependent Hippocampal Long-term Potentiation.

October 22, 2012
Charles. A. Hoeffer, Emanuela Santini, Tao Ma, Elizabeth C. Arnold, Ashley M. Whelan, Helen Wong, Philip Pierre, Jerry Pelletier, and Eric Klann http://jn.physiology.org/content/early/2012/10/05/jn.00342.2012.long ...
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Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer’s Disease Model Mice.

October 5, 2012
Tao Ma, Xueliang Du, Joseph E. Pick, Guangzhi Sui, Micheal Brownlee, and Eric Klann http://www.jneurosci.org/content/32/40/13701   ...
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The molecular basis of cognitive deficits in pervasive developmental disorders.

October 2, 2012
Aditi Bhattacharya and Eric Klann http://learnmem.cshlp.org/content/19/9/434.long Persons with pervasive developmental disorders (PDD) exhibit a range of cognitive deficits that hamper their quality of life, including difficulties involving communication, sociability, and perspective-taking. In recent years, a va...
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Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

June 12, 2012
Mimi A Trinh, Hanoch Kaphzan, Ronald C. Wek, Philippe Peirre, Douglas R. Cavener and Eric Klann http://www.cell.com/cell-reports/abstract/S2211-1247(12)00123-4 ...
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Fragile X syndrome therapeutics S(C)TEP through the developmental window

May 31, 2012
Aditi Bhattacharya and Eric Klann http://www.ncbi.nlm.nih.gov/pubmed/22500622 ...
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